DoxyPEP (gonorrhea, syphilis, chlamydia prevention) can be booked online.
Order OnlineWhat is Chlamydia?
Chlamydia (Chlamydia trachomatis) is one of the most common sexually transmitted infections in Japan. Many infected individuals are asymptomatic and remain unaware of their condition, leading to a risk of unknowingly spreading the infection to partners.
Main Symptoms
For men
- Urethral discharge
- Urinary discomfort/pain
- Swelling or pain in the testicles (epididymitis)
- Often asymptomatic
For women
- Increased or abnormal vaginal discharge
- Irregular bleeding
- Lower abdominal pain
- Often asymptomatic, can sometimes lead to infertility
Pharyngeal infection from oral sex
- Sore throat/discomfort
- Mostly asymptomatic
Transmission Routes and Precautions
Chlamydia is transmitted through mucous membrane contact (sexual intercourse, oral sex, anal sex). While condoms can offer some protection, they do not cover all areas of mucous membrane contact. Since chlamydia is often asymptomatic, regular testing is crucial after engaging in risky behaviors.
What is Syphilis?
Syphilis (Treponema pallidum) is a sexually transmitted infection that has been rapidly increasing in Japan recently. The symptoms appear and disappear in cycles as the infection progresses, and if left untreated, it can cause serious effects throughout the body.
Stages of Syphilis Progression
| Stage | Period | Main Symptoms |
|---|---|---|
| Primary | 3–6 weeks after infection | A painless sore (chancre) appears at the site of infection (genitals, lips, anus, etc.). It often goes unnoticed as it disappears naturally. |
| Secondary | 3 months – 3 years after infection | Rash (syphilitic roseola) all over the body, including palms and soles, fever, fatigue, swollen lymph nodes. |
| Latent | After secondary stage | Symptoms disappear, but bacteria continue to multiply in the body. |
| Tertiary/Quaternary | Several years after infection | Severe damage to the heart, blood vessels, nerves, brain, etc. |
If you experience any of these, please consult us as soon as possible:
- Painless lump on genitals, lips, or anus
- Rash on palms or soles
- Had sex with multiple partners
- Partner was diagnosed with syphilis
Can it be transmitted through kissing?
Syphilis can be transmitted through kissing alone. If there are syphilitic lesions on the lips or in the mouth, there is a risk of infection through mucous membrane contact during kissing. Since it cannot be said that "it's okay just because it's kissing," please consult us as soon as possible if you have any concerning symptoms.
What is Gonorrhea (Gonococcal Infection)?
Gonorrhea (Neisseria gonorrhoeae) is a sexually transmitted infection caused by gonococcus, and like chlamydia, it is common in Japan. While symptoms tend to be severe, antibiotic-resistant gonorrhea, which is difficult to treat with antibiotics, has become a problem in recent years.
Main Symptoms
For Men
- Severe pain and burning sensation during urination
- Purulent discharge from the urethra
- If left untreated, can progress to epididymitis and prostatitis
For Women
- Purulent vaginal discharge
- Pain during urination
- Often asymptomatic; if left untreated, can lead to pelvic inflammatory disease and infertility
Pharyngeal infection (due to oral sex)
- Sore throat/discomfort
- Mostly asymptomatic, making it hard to notice
If you experience any of these, please consult us as soon as possible:
- Severe pain or burning sensation during urination
- Purulent discharge from the urethra or vagina
- Had oral sex without a condom
- Partner was diagnosed with gonorrhea
What is DoxyPEP (Doxycycline Post-Exposure Prophylaxis)?
DoxyPEP (Doxycycline Post-Exposure Prophylaxis) is a method to prevent sexually transmitted infections such as chlamydia, syphilis, and gonorrhea by taking doxycycline (an antibiotic) after sexual intercourse.
According to research, DoxyPEP has been reported to have a preventative effect of approximately 87% against syphilis, 88% against chlamydia, and 55% against gonorrhea. It is an effective option for emergency prevention in situations where unprotected sex has occurred or where there is a high risk of STI.
Statement Regarding Unapproved Drugs
The doxycycline (Vibramycin) used at our clinic for STI prevention (DoxyPEP) is an off-label use as it is not approved for this indication in Japan. It is imported by our clinic through a formal process with the Ministry of Health, Labour and Welfare, and is provided as a self-pay service not covered by insurance. Clarification on the availability of approved drugs in Japan: Yes
Consider DoxyPEP if any of these apply:
- Had unprotected sex
- Condom broke or came off during sex
- Had sex with multiple partners
- Uncertain about partner's STI status
Preventative Effects of DoxyPEP
Target STIs and their preventative effects
| STI | Preventative Effect | Main Symptoms |
|---|---|---|
| Chlamydia | Approx. 88% | Pain during urination, abnormal discharge, pharyngitis, etc. (often asymptomatic) |
| Syphilis | Approx. 87% | Lumps on genitals/lips, rash, swollen lymph nodes, etc. |
| Gonorrhea | Approx. 55% | Severe pain during urination, purulent discharge, etc. |
STIs not prevented by DoxyPEP
DoxyPEP is not effective in preventing HIV, Hepatitis B, Herpes, HPV (genital warts), etc. If you are concerned about these, please consider purchasing PEP (for HIV), STI treatment medication, or testing kits separately.
How to take
Must be taken within 72 hours
DoxyPEP must be taken as soon as possible after sexual activity, and within a maximum of 72 hours (3 days). The preventative effect decreases over time.
Dosing Schedule
| Timing | Dosage |
|---|---|
| As soon as possible after sexual activity (within 72 hours maximum) | 200mg (two 100mg tablets) |
Take once per sexual encounter. Even if you have multiple sexual encounters, no additional dose is needed within 24 hours.
About Side Effects
Main Side Effects
- Nausea/stomach discomfort (can be reduced by taking with food)
- Photosensitivity (skin may turn red when exposed to sunlight)
- Diarrhea
Precautions
- Not for use by pregnant or breastfeeding individuals.
- Avoid taking with milk, antacids, or iron supplements (absorption will be reduced).
- Avoid prolonged exposure to sunlight and UV rays.
Prescription Process at Our Clinic
Step ① Provisional Payment & Pre-consultation Questionnaire
Please select your desired plan (number of times) and place your order. After ordering, please answer the questionnaire sent via LINE or email.
Step ② Online Consultation
A doctor will conduct counseling and prescribe via video call. All you need is a smartphone or PC.
Step ③ Same-day Shipping Possible
For video calls completed by 3:00 PM daily, shipping will be on the same day. Packages are delivered with privacy-conscious packaging.
※If you wish for same-day shipping, please notify us via LINE as early as possible.
