Rybelsus can be prescribed online.
Order OnlineRybelsus is a GLP-1 receptor agonist with the active ingredient "semaglutide" and is a medication that promotes weight loss. The active ingredient is the same as the injectable medication Ozempic.
The most significant feature of Rybelsus is that it is the only oral GLP-1 receptor agonist. GLP-1, which was difficult to absorb in the stomach, has been successfully made into an oral medication by using an absorption enhancer (SNAC), making it a groundbreaking drug that can be used even by patients who are uncomfortable with injections.
Rybelsus comes in three strengths: 3mg, 7mg, and 14mg, and the color of the sheet varies by milligram.
Rybelsus has an appetite-suppressing effect
Rybelsus works by promoting insulin secretion in a glucose-dependent manner (only when blood glucose levels rise) to lower blood glucose to normal levels and prevent a sudden rise in blood glucose. It also slows down gastrointestinal motility, thereby preventing hunger. Therefore, taking Rybelsus naturally suppresses appetite, prolongs satiety, and reduces the feeling of hunger.
This effect leads to an unconscious reduction in food intake and has been reported in many papers to be effective for weight loss, and its use for diet purposes has recently become widespread worldwide.
Some people might think that in human trials, the reduction in food intake might be due to conscious restraint for the sake of the paper, but this effect has also been proven in animal experiments, where the amount of food consumed by animals also naturally decreases. This demonstrates how effectively GLP-1 receptor agonists can suppress appetite naturally without effort.
GLP-1 receptor agonists are also attracting attention from the perspective of preventive medicine
Originally, Rybelsus (a GLP-1 receptor agonist) was an effective medication for controlling blood glucose levels in type 2 diabetes and reducing cardiovascular risk due to weight loss. It was approved in Japan in 2020 and went on sale in February 2021.
Obesity is considered a more significant risk factor in countries where preventive medicine is advanced, such as the United States, than in Japan, and is linked to the risk of myocardial infarction, cerebral infarction, and fatty liver disease. Therefore, GLP-1 receptor agonists (such as Rybelsus) were developed for patients who struggle to lose weight even with diet and exercise, and they are approved as "anti-obesity drugs" in various countries around the world, including the United States and Europe.
Column: A revolutionary invention! What makes oral semaglutide (Rybelsus) so amazing?!
Originally, semaglutide had a large molecular weight, making absorption in the digestive tract difficult, and injection was the only option. Oral administration was unsuitable because semaglutide would be broken down by digestive enzymes in the stomach. However, by including SNAC, an absorption enhancer, degradation was inhibited, and absorption in the stomach was promoted, making oral administration of GLP-1 semaglutide possible for the first time in the world (1*).
Can Rybelsus be used for dieting?
Rybelsus was originally used as a diabetes treatment.
Always get a doctor's prescription even for diet purposes!
Rybelsus is a GLP-1 receptor agonist that mimics the action of GLP-1, a hormone naturally present in the body. When blood glucose levels rise after a meal, GLP-1 acts on various organs to induce satiety and suppress a rapid increase in blood glucose. It was approved in Japan as a treatment for type 2 diabetes in 2020 and became available for sale in January 2021.
Although it is approved in Japan for type 2 diabetes, it is also used for obesity prevention and diet purposes as a self-pay treatment not covered by health insurance. This is because it controls blood glucose levels and slows down stomach movement, which naturally suppresses appetite, leading to reduced calorie intake and the expectation of natural weight loss.
As mentioned above, GLP-1 originally has the effect of promoting satiety after meals. Therefore, GLP-1 receptor agonists can make you feel full for longer than usual, naturally suppressing hunger and allowing you to reduce your food intake without stressful dietary restrictions. Furthermore, GLP-1 has a wide range of effects, including reducing the risk of fatty liver by acting on the liver and increasing metabolism by acting on brown adipose tissue.
Rybelsus is a medicine, and it is necessary to check contraindications, medical history, and concomitant use with other medications before use. Therefore, a doctor's examination and prescription are absolutely necessary to take Rybelsus.
Diet effectively with Rybelsus!
GLP-1 is a hormone naturally present in the body that is secreted from the small intestine when we eat, and it acts on the appetite-controlling nerves in the brain to suppress appetite. It slows down gastrointestinal movement to prolong satiety and acts on the pancreas to prevent a rapid rise in blood glucose. By increasing the amount of GLP-1 in the body, you can feel satisfied with smaller meals, naturally reducing your calorie intake and allowing you to maintain a healthy diet without stress.
Rybelsus allows you to experience the effects of GLP-1 by taking it once a day on an empty stomach. It can be used with confidence by those who are hesitant about injections and have been unable to start GLP-1 dieting, those who find injections inconvenient to carry, and those who want to start easily.
How much weight can you lose with Rybelsus?
Although appetite suppression is seen early, it is not a medication for significant short-term weight loss.
Many people experience weight loss around 3 months after starting administration, and clinical trials often assess effectiveness after 6 to 12 months of continuous use. Of course, some people lose weight in the first month, but it's more accurate to think of it as a gradual weight loss rather than rapid weight loss.
GLP-1 receptor agonists are basically medications that lead to weight loss by stress-free reduction of food intake, i.e., calorie intake, so they are not medications that cause rapid weight loss in a few days (even if you skip dinner, you won't lose weight quickly in a short period, will you?). Also, rapid weight loss diets are often prone to rebound. The goal is to reduce calorie intake within a reasonable range without stress and gradually lose weight in a healthy manner.
That being said, many people want to see results as quickly as possible. Our clinic carefully consults with patients about their goals (e.g., having a wedding in 3 months, a reunion) and helps them achieve results.
Our clinic also partners with gyms. We offer advice on diet and exercise in parallel, so please feel free to contact us. We don't just prescribe medication; we support those who are serious about losing weight in achieving their "ideal self."
References:
(1) MSD "Mechanism of Action of Rybelsus" https://www.msdconnect.jp/products/rybelsus/info/action-mechanism/
(2): Aroda, V. R. et al. PIONEER 1: Randomized Clinical Trial of the Efficacy and Safety of Oral Semaglutide Monotherapy in Comparison With Placebo in Patients With Type 2 Diabetes. Diabetes Care 42, 1724–1732 (2019).
(3): Rybelsus Official Document
(4): Buckley, S. T. et al. Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist. Sci Transl Med 10, (2018).
